Palliative cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion: current clinical practice or misnomer

UMMS Affiliation

Department of Surgery, Division of Surgical Oncology

Publication Date


Document Type



Gastroenterology | Oncology | Surgery


Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS/HIPEC) is being used more and more frequently for the management of peritoneal carcinomatosis. Despite significant improvements in oncologic outcomes and the risk of complications and mortality, CRS/HIPEC remains one of the most morbid treatments offered for advanced cancers. Consequently CRS/HIPEC is still considered controversial by many, even in the setting of cancers that are potentially curable. However, as high volume surgical oncologists become more experienced with CRS/HIPEC, the potential role of "palliative CRS/HIPEC" in the management of peritoneal carcinomatosis is being raised. Given the often limited survival benefit expected after CRS/HIPEC, understanding the impact of the treatment on quality of life (QOL) needs to be an essential part of the decision to proceed and is critical to optimizing recovery afterwards. This article reviews the potential definitions of "palliative CRS/HIPEC" in various clinical contexts and describes the current state of the QOL experience after CRS/HIPEC.


Hyperthermic intraperitoneal chemoperfusion (HIPEC), carcinomatosis, cytoreductive surgery (CRS), palliative surgery, quality of life (QOL)

DOI of Published Version



J Gastrointest Oncol. 2016 Feb;7(1):112-21. doi: 10.3978/j.issn.2078-6891.2015.132. Link to article on publisher's site

Journal/Book/Conference Title

Journal of gastrointestinal oncology

Related Resources

Link to Article in PubMed

PubMed ID