Department of Obstetrics and Gynecology
Female Urogenital Diseases and Pregnancy Complications | Neoplasms | Women's Health
Endometriosis is a benign gynecological condition characterized by specific histological, molecular, and clinical findings. It affects 5%-10% of premenopausal women, is a cause of infertility, and has been implicated as a precursor for certain types of ovarian cancer. Advances in technology, primarily the ability for whole genome sequencing, have led to the discovery of new mutations and a better understanding of the function of previously identified genes and pathways associated with endometriosis associated ovarian cancers (EAOCs) that include PTEN, CTNNB1 (beta-catenin), KRAS, microsatellite instability, ARID1A, and the unique role of inflammation in the development of EAOC. Clinically, EAOCs are associated with a younger age at diagnosis, lower stage and grade of tumor, and are more likely to occur in premenopausal women when compared with other ovarian cancers. A shift from screening strategies adopted to prevent EAOCs has resulted in new recommendations for clinical practice by national and international governing bodies. In this paper, we review the common histologic and molecular characteristics of endometriosis and ovarian cancer, risks associated with EAOCs, clinical challenges and give recommendations for providers.
clinical, inflammation, molecular, pathways, premenopausal
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Copyright © 2015 Pavone and Lyttle. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
DOI of Published Version
Int J Womens Health. 2015 Jul 1;7:663-72. doi: 10.2147/IJWH.S66824. eCollection 2015. Link to article on publisher's site
International journal of women's health
Pavone, Mary Ellen and Lyttle, Brianna M., "Endometriosis and ovarian cancer: links, risks, and challenges faced" (2015). Open Access Articles. 2734.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License