Reactive oxygen species in endothelial function - from disease to adaptation -

UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date


Document Type



Acetylcholine; *Adaptation, Physiological; Animals; Anoxia; Cardiovascular Diseases; Endothelium, Vascular; Endothelium-Dependent Relaxing Factors; Humans; NADPH Oxidase; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Vascular Resistance; Vasculitis; Vasodilation


Cardiology | Cardiovascular Diseases | Inorganic Chemicals


Endothelial function is largely dictated by its ability to rapidly sense environmental cues and adapt to these stimuli through changes in vascular tone, inflammation/immune recruitment, and angiogenesis. When any one of these abilities is compromised, the endothelium becomes dysfunctional, which ultimately leads to disease. Reactive oxygen species (ROS) have been established at the forefront of endothelial dysfunction; however, more careful examination has demonstrated that ROS are fundamental to each of the sensing/signaling roles of the endothelium. The purpose of this review is to document endothelial ROS production in both disease and physiological adaptation. Through understanding new endothelial signaling paradigms, we will gain insight into more targeted therapeutic strategies for vascular diseases.

DOI of Published Version



Circ J. 2015;79(6):1145-55. doi: 10.1253/circj.CJ-15-0464. Epub 2015 May 18. Link to article on publisher's site

Journal/Book/Conference Title

Circulation journal : official journal of the Japanese Circulation Society

Related Resources

Link to Article in PubMed

PubMed ID