UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Publication Date

2015-11-09

Document Type

Article

Disciplines

Cell Biology | Cellular and Molecular Physiology

Abstract

Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.

Keywords

Autophagy, Macroautophagy

Rights and Permissions

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

DOI of Published Version

10.1038/cddiscovery.2015.36

Source

Cell Death Discovery (2015) 1, 15036; doi:10.1038/cddiscovery.2015.36. Link to article on publisher's site

Journal/Book/Conference Title

Cell death discovery

Related Resources

Link to Article in PubMed

PubMed ID

26682061

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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