UMMS Affiliation
Department of Molecular, Cell and Cancer Biology
Publication Date
2015-11-09
Document Type
Article
Disciplines
Cell Biology | Cellular and Molecular Physiology
Abstract
Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.
Keywords
Autophagy, Macroautophagy
Rights and Permissions
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1038/cddiscovery.2015.36
Source
Cell Death Discovery (2015) 1, 15036; doi:10.1038/cddiscovery.2015.36. Link to article on publisher's site
Journal/Book/Conference Title
Cell death discovery
Related Resources
PubMed ID
26682061
Repository Citation
Lindqvist, L M.; Simon, A K.; and Baehrecke, Eric H., "Current questions and possible controversies in autophagy" (2015). Open Access Articles. 2680.
https://escholarship.umassmed.edu/oapubs/2680
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.