UMMS Affiliation

Department of Molecular, Cell and Cancer Biology

Publication Date


Document Type



Cell Biology | Cellular and Molecular Physiology


Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.


Autophagy, Macroautophagy

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DOI of Published Version



Cell Death Discovery (2015) 1, 15036; doi:10.1038/cddiscovery.2015.36. Link to article on publisher's site

Journal/Book/Conference Title

Cell death discovery

Related Resources

Link to Article in PubMed

PubMed ID


Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.