Department of Medicine, Division of Infectious Diseases and Immunology
Immunology of Infectious Disease | Infectious Disease | International Public Health | Virus Diseases
BACKGROUND: Dengue is the most prevalent arthropod-borne viral illness in humans with half of the world's population at risk. During early infancy, severe dengue can develop after a primary dengue virus infection. There has been a clinical observation that severe dengue during the first year of life is seen only in chubby infants.
METHODOLOGY/PRINCIPAL FINDINGS: We examined the associations between the development of severe dengue and adipose tissue accumulation patterns during the first year of life in a prospective observational clinical study of infants and dengue virus infections. We found that adipose tissue contains two potential targets for dengue virus infection and production- adipocytes and adipose tissue macrophages. During the first year of life, total body adiposity and visceral adipose tissue stores were at their highest levels in early infancy. Early infancy was also characterized by a relative decrease in alternatively activated (anti-inflammatory) macrophages, and a relative increase in circulating pro-inflammatory cytokines.
CONCLUSIONS/SIGNIFICANCE: The data has been used to propose a model where the adipose tissue accumulation pattern and pro-inflammatory environment during early infancy provide the conditions for the potential development of severe dengue in immune-susceptible infants.
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Copyright 2015 Libraty et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
PLoS Negl Trop Dis. 2015 Dec 4;9(12):e0004267. doi: 10.1371/journal.pntd.0004267. eCollection 2015. Link to article on publisher's site
PLoS neglected tropical diseases
Libraty, Daniel H.; Wang, Pengyan; Guo, Zhiru; Bigcas, Venelle; Brion, Job D.; and Capeding, Rosario Z., "The Pattern of Adipose Tissue Accumulation during Early Infancy Provides an Environment for the Development of Dengue Hemorrhagic Fever" (2015). Open Access Articles. 2654.
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This work is licensed under a Creative Commons Attribution 4.0 License.