UMMS Affiliation
Department of Pathology
Publication Date
2015-08-05
Document Type
Article
Disciplines
Immune System Diseases | Immunopathology | Molecular and Cellular Neuroscience | Nervous System Diseases
Abstract
Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System (CNS) that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons and axons. Historically, MS has been thought of as a T cell-mediated autoimmune disease of CNS white matter. However, recent studies have identified gray matter lesions in MS patients, suggesting that CNS antigens other than myelin proteins may be involved during the MS disease process. We have recently found that T cells targeting astrocyte-specific antigens can drive unique aspects of inflammatory CNS autoimmunity, including the targeting of gray matter and white matter of the brain and inducing heterogeneous clinical disease courses. In addition to being a target of T cells, astrocytes play a critical role in propagating the inflammatory response within the CNS induced NF-kappaB signaling. Here, we will discuss the pathophysiology of CNS inflammation mediated by T cell-glial cell interactions and its contributions to CNS autoimmunity.
Keywords
T cell, astrocytes, autoimmunity, cerebellum, experimental autoimmune encephalomyelitis, glial fibrillary acidic protein, multiple sclerosis
Rights and Permissions
Copyright © 2015 Huseby, Kamimura, Arima, Parello, Sasaki and Murakami. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI of Published Version
10.3389/fncel.2015.00295
Source
Front Cell Neurosci. 2015 Aug 5;9:295. doi: 10.3389/fncel.2015.00295. eCollection 2015. Link to article on publisher's site
Journal/Book/Conference Title
Frontiers in cellular neuroscience
Related Resources
PubMed ID
26300731
Repository Citation
Huseby E, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. (2015). Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms. Open Access Publications by UMMS Authors. https://doi.org/10.3389/fncel.2015.00295. Retrieved from https://escholarship.umassmed.edu/oapubs/2631
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Immune System Diseases Commons, Immunopathology Commons, Molecular and Cellular Neuroscience Commons, Nervous System Diseases Commons