UMMS Affiliation
Department of Medicine, Division of Hematology-Oncology
Publication Date
2015-06-01
Document Type
Article
Disciplines
Hemic and Lymphatic Diseases | Neoplasms | Oncology | Surgery
Abstract
BACKGROUND: Patients with lymph node-negative gastric cancer show a better overall survival rate than those who have a pathological lymph node-positive gastric cancer. But a large number of patients still develop recurrence. We aimed to explore the significant prognostic factors of lymph node-negative gastric cancer and determine how many lymph nodes should be removed.
METHODS: A total of 3103 patients who underwent radical operation are identified from the Surveillance, Epidemiology, and End Results database. Standard survival methods and restricted multivariable Cox regression models were applied.
RESULTS: The overall survival rate was significantly higher with an increasing number of negative lymph node resected. Among the 843 patients who had the exact T stage, the overall survival rate was significantly better in T3-4 group with more than 15 lymph nodes resected (P < 0.001) but not in T1-2 stage patients (P = 0.44). A further 25 more lymph nodes resection did not show additional survival benefits. Multivariate analysis of patients demonstrated that age, depth of tumor invasion, and the number of lymph nodes resected were the significant and independent prognostic factors.
CONCLUSIONS: A lymphadenectomy with more than 15 lymph nodes removal should be performed for T3-4 lymph node-negative gastric cancer. But the survival benefit of a lymphadenectomy with more than 25 lymph nodes removal is disputed. And the further treatment should refer to the prognostic indicators.
Rights and Permissions
© 2015 Chu and Yang. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI of Published Version
10.1186/s12957-015-0602-x
Source
World J Surg Oncol. 2015 Jun 1;13:192. doi: 10.1186/s12957-015-0602-x. Link to article on publisher's site
Journal/Book/Conference Title
World journal of surgical oncology
Related Resources
PubMed ID
26026805
Repository Citation
Chu X, Yang Z. (2015). Impact on survival of the number of lymph nodes resected in patients with lymph node-negative gastric cancer. Open Access Articles. https://doi.org/10.1186/s12957-015-0602-x. Retrieved from https://escholarship.umassmed.edu/oapubs/2563
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Hemic and Lymphatic Diseases Commons, Neoplasms Commons, Oncology Commons, Surgery Commons