School of Medicine
Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Neoplasms | Nephrology | Oncology
Renal failure (RF) reversal in multiple myeloma (MM) is associated with an improved prognosis. Light chain myeloma, serum creatinine (SCr) > 4 mg/dL, extensive proteinuria, early infections, and certain renal biopsy findings are associated with lower rates of RF reversal. Our patient is a 67-year-old female with multiple poor prognostic factors for RF reversal who demonstrated a rapid renal response with bortezomib and dexamethasone (BD) regimen. She presented initially with altered mental status. On exam, she appeared lethargic and dehydrated and had generalized tenderness. She had been taking ibuprofen as needed for pain for a few weeks. Labs showed a white cell count-18,900/muL with no bandemia, hemoglobin 10.8 gm/dL, potassium-6.7 mEq/L, bicarbonate-15 mEq/L, blood urea nitrogen-62 mg/dL, SCr-5.6 mg/dL (baseline: 1.10), and corrected calcium-11.8 mg/dL. A rapid flu test was positive. Imaging studies were unremarkable. Her EKG showed sinus tachycardia and her urinalysis was unremarkable. The unexplained RF in an elderly individual in conjunction with hypercalcemia and anemia prompted a MM work-up; eventually, lambda variant MM was diagnosed. An immediate (4 days) renal response defined as 50% reduction in SCr was noticed after initiation of the BD regimen.
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Copyright © 2014 Bhanu K. Patibandla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI of Published Version
Case Rep Nephrol. 2014;2014:940171. doi: 10.1155/2014/940171. Epub 2014 Jun 19. Link to article on publisher's site
Case reports in nephrology
Patibandla BK, Narra A, Alwassia AA, Bartley A, Sandhu GS, Rooney J, Black RM. (2014). Case report on renal failure reversal in lambda chain multiple myeloma with bortezomib and dexamethasone. Open Access Publications by UMass Chan Authors. https://doi.org/10.1155/2014/940171. Retrieved from https://escholarship.umassmed.edu/oapubs/2557
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.