Department of Internal Medicine
Alternative and Complementary Medicine | Digestive System Diseases | Neoplasms | Oncology
Oldenlandia diffusa (OD) is commonly used with various diseases such as cancer, arthritis, and autoimmune disease. Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). Here, we show that the therapeutic effect of OD, which was investigated both in vitro and chemically, induced HCC model. OD significantly enhanced apoptosis and antiproliferative activity and reduced migration ability of HCC cells. In vivo, OD was treated twice a day for 28 days after confirmed HCC model through 2-[(18)F]-fluoro-2-deoxy-D-glucose ((18)F-FDG) imaging. The survival in OD treated groups was shown to have a greater therapeutic effect than the control group. 28 days after OD treatment, OD treated groups resulted in a significant reduction in tumor number, size, (18)F-FDG uptake, and serum levels such as alanine transaminase, aspartate transaminase, and alkaline phosphate compared to the control group. Also, proliferated cells in tumor sites by OD were reduced compared to the control group. Furthermore, several rats in OD treated group survived over 60 days and liver morphology of these rats showed the difference between tumor mass and normal tissue. These results suggest that OD may have antiproliferative activity, inhibition of metastasis, and apoptotic effects in chemically induced HCC model and can have the potential use for clinical application as anticancer drug of the herbal extract.
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Copyright © 2015 Yun-Young Sunwoo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI of Published Version
Evid Based Complement Alternat Med. 2015;2015:501508. doi: 10.1155/2015/501508. Epub 2015 Mar 10. Link to article on publisher's site
Evidence-based complementary and alternative medicine : eCAM
Sunwoo Y, Lee J, Jung HY, Jung YJ, Park M, Chung Y, Maeng L, Han Y, Shin HS, Lee J, Park SI. (2015). Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Open Access Articles. https://doi.org/10.1155/2015/501508. Retrieved from https://escholarship.umassmed.edu/oapubs/2556
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.