Department of Psychiatry, Psychotic Disorders Research Program
Adult; Alleles; Antipsychotic Agents; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Male; *Polymorphism, Single Nucleotide; Proteins; Risperidone; Schizophrenia; Weight Gain; Young Adult
Medical Neurobiology | Mental Disorders | Molecular and Cellular Neuroscience | Psychiatric and Mental Health | Psychiatry
BACKGROUND: Obesity induced by antipsychotics severely increases the risk of many diseases and significantly reduces quality of life. Genome Wide Association Studies has identified fat-mass and obesity-associated (FTO) gene associated with obesity. The relationship between the FTO gene and drug-induced obesity is unclear.
METHOD: Two hundred and fifty drug naive, Chinese Han patients with first-episode schizophrenia were enrolled in the study, and genotyped for four single nucleotide polymorphisms (SNPs rs9939609, rs8050136, rs1421085 and rs9930506) by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing. Body weight and body mass index (BMI) were measured at baseline and six months after risperidone treatment.
RESULTS: At baseline, body weight and BMI of TT homozygotes were lower than those of A allele carriers in rs9939609; body weight of AA homozygotes was higher than those of G allele carriers in rs9930506 (p's < 0.05). After 6 months of risperidone treatment, body weight and BMI of TT homozygotes were lower than those of A allele carriers in rs9939609 (p's < 0.01); body weight and BMI of CC homozygotes were lower than those of A allele carriers in rs8050136 (p's < 0.05); body weight of AA homozygotes was higher than those of G allele carriers in rs9930506 (p's < 0.05). After controlling for age, gender, age of illness onset, disease duration, weight at baseline and education, weight gain of TT homozygotes at 6 months remained to be lower than those of A allele carriers in rs9939609 (p < 0.01); weight gain of CC homozygotes at 6 months was lower than those of A allele carriers in rs8050136 (p = 0.01). Stepwise multiple regression analysis suggested that, among 4 SNPs, rs9939609 was the strongest predictor of weight gain after 6 months of risperidone treatment (p = 0.001).
CONCLUSIONS: The FTO gene polymorphisms, especially rs9939609, seem to be related to weight gain after risperidone treatment in Chinese Han patients with first episode schizophrenia.
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DOI of Published Version
Behav Brain Funct. 2014 Oct 2;10(1):35. doi: 10.1186/1744-9081-10-35. Link to article on publisher's site
Behavioral and brain functions : BBF
Song, Xueqin; Pang, Lijuan; Feng, Yufang; Fan, Xiaoduo; Li, Xue; Zhang, Wei; Gao, Jinsong; Zhang, Jianjiang; Nemani, Katlyn; Zhang, Hua; and Lv, Luxian, "Fat-mass and obesity-associated gene polymorphisms and weight gain after risperidone treatment in first episode schizophrenia" (2014). Open Access Articles. 2518.
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