UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
2014-04-11
Document Type
Article
Subjects
Adult; Anthropometry; Biological Markers; *Coffee; *Drinking Behavior; Female; Fibronectins; Humans; Male
Disciplines
Endocrinology, Diabetes, and Metabolism | Medical Physiology | Physiology
Abstract
Irisin, secreted by skeletal muscle and possibly fat, is hypothesized to play an important role in modulating energy expenditure, obesity and metabolism. Coffee consumption also increases energy expenditure and leads to positive metabolic effects, but whether these effects are mediated by irisin remains unknown. The objective of this study was to determine the association between baseline irisin levels and the metabolic profile in humans and to investigate whether consumption of caffeinated coffee alters irisin levels. To this end, a secondary analysis was performed investigating irisin levels at baseline and after eight weeks in 32 healthy, overweight coffee drinkers who were randomized to consumption of 5 cups per day of instant caffeinated coffee, decaffeinated coffee, or water. Spearman correlation and analysis of covariance analyses were performed to identify possible associations. Irisin levels were positively correlated with waist circumference (r = 0.41, p = 0.02), fat mass (r = 0.44, p = 0.01) and CRP (r = 0.47, p = 0.007). Though there was a trend towards increased levels of irisin over time in the caffeinated coffee group (+1.8%) when compared to the placebo group (24%) this did not reach statistical significance (p = 0.75 for the trend). This first randomized trial failed to reveal any effects of coffee consumption on irisin levels, but a larger trial, appropriately sized on the basis of data provided by this study, is needed to conclusively investigate such a relationship. TRIAL REGISTRATION: Clinicaltrials.gov NCT00305097.
Keywords
caffeine, coffee consumption, irisin
Rights and Permissions
Copyright: © 2014 Peter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
10.1371/journal.pone.0094463
Source
PLoS One. 2014 Apr 11;9(4):e94463. doi: 10.1371/journal.pone.0094463. Link to article on publisher's site
Journal/Book/Conference Title
PloS one
Related Resources
PubMed ID
24728416
Repository Citation
Peter PR, Park KH, Huh JY, Wedick NM, Mantzoros CS. (2014). Circulating irisin levels are not affected by coffee intake: a randomized controlled trial. Open Access Articles. https://doi.org/10.1371/journal.pone.0094463. Retrieved from https://escholarship.umassmed.edu/oapubs/2484
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Endocrinology, Diabetes, and Metabolism Commons, Medical Physiology Commons, Physiology Commons