Department of Medicine
Bacterial Infections and Mycoses | Endocrine System Diseases | Immunology of Infectious Disease | Respiratory Tract Diseases
BACKGROUND: Cytokines play an important role in the pathogenesis of pulmonary tuberculosis (PTB)--Type 2 diabetes mellitus co-morbidity. However, the cytokine interactions that characterize PTB coincident with pre-diabetes (PDM) are not known.
METHODS: To identify the influence of coincident PDM on cytokine levels in PTB, we examined circulating levels of a panel of cytokines in the plasma of individuals with TB-PDM and compared them with those without PDM (TB-NDM).
RESULTS: TB-PDM is characterized by elevated circulating levels of Type 1 (IFNgamma, TNFalpha and IL-2), Type 17 (IL-17A and IL-17F) and other pro-inflammatory (IL-1beta, IFNbeta and GM-CSF) cytokines. TB-PDM is also characterized by increased systemic levels of Type 2 (IL-5) and regulatory (IL-10 and TGFbeta) cytokines. Moreover, TB antigen stimulated whole blood also showed increased levels of pro-inflammatory (IFNgamma, TNFalpha and IL-1beta) cytokines as well. However, the cytokines did not exhibit any significant correlation with HbA1C levels or with bacterial burdens.
CONCLUSION: Our data reveal that pre-diabetes in PTB individuals is characterized by heightened cytokine responsiveness, indicating that a balanced pro and anti - inflammatory cytokine milieu is a feature of pre-diabetes--TB co-morbidity.
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DOI of Published Version
PLoS One. 2014 Nov 13;9(11):e112108. doi: 10.1371/journal.pone.0112108. eCollection 2014. Link to article on publisher's site
Kumar, Nathella Pavan; Banurekha, Vaithilingam V.; Nair, Dina; Sridhar, Rathinam; Kornfeld, Hardy; Nutman, Thomas B.; and Babu, Subash, "Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis" (2014). Open Access Articles. 2467.
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