Preliminary evaluation of near infrared spectroscopy as a method to detect plasma leakage in children with dengue hemorrhagic fever
Authors
Soller, Babs R.Srikiatkhachorn, Anon
Zou, Fengmei
Rothman, Alan L.
Yoon, In-Kyu
Gibbons, Robert V.
Kalayanarooj, Siripen
Thomas, Stephen J.
Green, Sharone
UMass Chan Affiliations
Department of Medicine, Division of Infectious Disease and ImmunologyDepartment of Anesthesiology
Document Type
Journal ArticlePublication Date
2014-07-17
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BACKGROUND: Dengue viral infections are prevalent in the tropical and sub-tropical regions of the world, resulting in substantial morbidity and mortality. Clinical manifestations range from a self-limited fever to a potential life-threatening plasma leakage syndrome (dengue hemorrhagic fever). The objective of this study was to assess the utility of near infrared spectroscopy (NIRS) measurements of muscle oxygen saturation (SmO2) as a possible continuous measure to detect plasma leakage in children with dengue. METHODS: Children ages 6 months to 15 years of age admitted with suspected dengue were enrolled from the dengue ward at Queen Sirikit National Institute for Child Health. Children were monitored daily until discharge. NIRS data were collected continuously using a prototype CareGuide Oximeter 1100 with sensors placed on the deltoid or thigh. Daily ultrasound of the chest and a right lateral decubitus chest x-ray the day after defervescence were performed to detect and quantitate plasma leakage in the pleural cavity. RESULTS: NIRS data were obtained from 19 children with laboratory-confirmed dengue. Average minimum SmO2 decreased for all subjects prior to defervescence. Average minimum SmO2 subsequently increased in children with no ultrasound evidence of pleural effusion but remained low in children with pleural effusion following defervescence. Average minimum SmO2 was inversely correlated with pleural space fluid volume. ROC analysis revealed a cut-off value for SmO2 which yielded high specificity and sensitivity. CONCLUSIONS: SmO2 measured using NIRS may be a useful guide for real-time and non-invasive identification of plasma leakage in children with dengue. Further investigation of the utility of NIRS measurements for prediction and management of severe dengue syndromes is warranted.Source
BMC Infect Dis. 2014 Jul 17;14:396. doi: 10.1186/1471-2334-14-396. Link to article on publisher's siteDOI
10.1186/1471-2334-14-396Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39644PubMed ID
25033831Related Resources
Link to Article in PubMedDistribution License
http://creativecommons.org/licenses/by/4.0/ae974a485f413a2113503eed53cd6c53
10.1186/1471-2334-14-396
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/