Department of Medicine, Division of Infectious Diseases and Immunology
Chitin; Chitosan; Immunity, Innate
Immunology and Infectious Disease
Chitin is the second most common polysaccharide found in nature. It is present in crustacean shells, insect exoskeletons, parasitic nematode eggs and gut linings, and in the cell wall of fungi. The deacetylated derivative of chitin, chitosan, is less common but is particularly evident in certain species of fungi, such as Cryptococcus, and the cyst wall of Entamoeba. How mammals sense and respond to these polymers is not well understood, and conflicting reports on their immunological activity have led to some controversy. Despite this, promising translational applications that exploit the unique properties of chitin and chitosan are being developed.
Rights and Permissions
Copyright: Bueter et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
PLoS Pathog. 2013 Jan;9(1):e1003080. doi: 10.1371/journal.ppat.1003080. Link to article on publisher's site
Bueter, Chelsea L.; Specht, Charles A.; and Levitz, Stuart M., "Innate sensing of chitin and chitosan" (2013). Open Access Articles. 2401.