UMMS Affiliation

Department of Neurology

Publication Date


Document Type



Adolescent; Adult; Bipolar Disorder; Female; Humans; Male; Middle Aged; Motor Activity; Young Adult


Life Sciences | Medicine and Health Sciences | Neurology


Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

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Copyright: © 2011 Indic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI of Published Version



Indic P, Salvatore P, Maggini C, Ghidini S, Ferraro G, et al. (2011) Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder. PLoS ONE 6(5): e20650. doi:10.1371/journal.pone.0020650. Link to article on publisher's site

Journal/Book/Conference Title

PloS one

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Link to Article in PubMed

PubMed ID