UMMS Affiliation

Department of Pediatrics; Department of Cell Biology

Publication Date


Document Type



Adult; Benzofurans; Dioxins; *Environmental Exposure; Environmental Pollutants; Female; Gas Chromatography-Mass Spectrometry; Humans; Longitudinal Studies; Polychlorinated Biphenyls; Russia; Young Adult


Cell Biology | Endocrinology, Diabetes, and Metabolism | Environmental Public Health | Life Sciences | Medicine and Health Sciences | Pediatrics


BACKGROUND: The present study assessed the temporal trend in serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls (PCBs) among residents of a Russian town where levels of these chemicals are elevated due to prior industrial activity.

METHODS: Two serum samples were collected from eight adult women (in 2000 and 2009), and analyzed with gas chromatography-high-resolution mass spectrometry.

RESULTS: The average total toxic equivalency (TEQ) decreased by 30% (from 36 to 25 pg/g lipid), and the average sum of PCB congeners decreased by 19% (from 291 to 211 ng/g lipid). Total TEQs decreased for seven of the eight women, and the sum of PCBs decreased for six of eight women. During this nine year period, larger decreases in serum TEQs and PCBs were found in women with greater increases in body mass index.

CONCLUSIONS: This study provides suggestive evidence that average serum concentrations of dioxins, furans, and PCBs are decreasing over time among residents of this town.

Rights and Permissions

© 2011 Humblet et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Environ Health. 2011 Jun 22;10:62. Link to article on publisher's site

Journal/Book/Conference Title

Environmental health : a global access science source

Related Resources

Link to Article in PubMed

PubMed ID