UMMS Affiliation

Department of Microbiology and Physiological Systems; Program in Cell Dynamics

Publication Date


Document Type



Cell Cycle Checkpoints; Cytokinesis; Actin Cytoskeleton; Protein-Serine-Threonine Kinases; Cell Polarity


Cell Biology | Cellular and Molecular Physiology


Regulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively. Our understanding of how these signaling pathways are coordinated to assist transition between the two cell-cycle stages is limited. Here, we review work from our laboratory, which reveals that cross talk between the SIN and MOR pathways is required for inhibition of interphase polarity programs during cytokinesis. Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms.

Rights and Permissions

© 2011 Gupta and McCollum; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI of Published Version



Cell Div. 2011 Nov 11;6:19. Link to article on publisher's site

Journal/Book/Conference Title

Cell division


First author Sneha Gupta is a doctoral student in the Interdisciplinary Graduate Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources

Link to Article in PubMed

PubMed ID