Department of Pathology
Amino Acid Sequence; Animals; HIV Envelope Protein gp41; Humans; Mice; *Models, Immunological; Molecular Sequence Data; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; Viruses
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences | Microbiology
In this Opinion, based on a novel model of immune signaling, the Signaling Chain HOmoOLigomerization (SCHOOL) model, I suggest specific mechanisms used by different viruses such as human immunodeficiency virus (HIV), cytomegalovirus (CMV), severe acute respiratory syndrome coronavirus (SARS-CoV), herpesvirus saimiri (HVS), human herpesvirus 6 (HHV-6), etc., to modulate the host immune response mediated by members of the family of multichain immune recognition receptors (MIRRs). I also demonstrate how the SCHOOL model, together with the lessons learned from viral pathogenesis, can be used practically for rational drug design and the development of new therapies for immune disorders.
Rights and Permissions
Copyright: © 2009 Alexander B. Sigalov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
Sigalov AB (2009) Novel Mechanistic Insights into Viral Modulation of Immune Receptor Signaling. PLoS Pathog 5(7): e1000404. doi:10.1371/journal.ppat.1000404. Link to article on publisher's site
Sigalov AB. (2009). Novel mechanistic insights into viral modulation of immune receptor signaling. Open Access Publications by UMMS Authors. https://doi.org/10.1371/journal.ppat.1000404. Retrieved from https://escholarship.umassmed.edu/oapubs/2201