Inflammasomes: too big to miss

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology; Department of Molecular Genetics and Microbiology

Publication Date


Document Type



Adaptor Proteins, Signal Transducing; Animals; Caspase 1; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Interleukin-1; Macromolecular Substances; Models, Immunological; Receptors, Immunologic; Signal Transduction


Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences


Inflammation is the coordinated immune response to harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue responses. These cells are equipped with an array of signaling receptors that detect foreign molecular substances or altered endogenous molecules that appear under situations of stress. This review provides an overview of recent progress in elucidating the molecular mechanisms that lead to inflammatory reactions. We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed "inflammasomes," which regulate the activity of caspase-1 and the maturation and release of IL-1beta.

DOI of Published Version



J Clin Invest. 2009 Dec;119(12):3502-11. doi: 10.1172/JCI40599. Epub 2009 Dec 1. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of clinical investigation

Related Resources

Link to Article in PubMed

PubMed ID