In search of nonribosomal nucleolar protein function and regulation

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date


Document Type



Animals; Cell Cycle; Cell Cycle Proteins; Cell Nucleolus; Humans; Nuclear Proteins; Phosphoric Monoester Hydrolases; Protein Transport; RNA Precursors; RNA, Ribosomal; Ribosomal Proteins


Life Sciences | Medicine and Health Sciences


The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring within the nucleolus. The questions of how and why these proteins end up in this subnuclear compartment remain unanswered and are the focus of intense current interest. This review discusses our thoughts on the discovery of nonribosomal proteins in the nucleolus.

DOI of Published Version



J Cell Biol. 2009 Mar 23;184(6):771-6. Epub 2009 Mar 16. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of cell biology

Related Resources

Link to Article in PubMed

PubMed ID