Department of Biochemistry and Molecular Pharmacology
Animals; Cell Cycle; Cell Cycle Proteins; Cell Nucleolus; Humans; Nuclear Proteins; Phosphoric Monoester Hydrolases; Protein Transport; RNA Precursors; RNA, Ribosomal; Ribosomal Proteins
Life Sciences | Medicine and Health Sciences
The life of the nucleolus has proven to be more colorful and multifaceted than had been envisioned a decade ago. A large number of proteins found in this subnuclear compartment have no identifiable tie either to the ribosome biosynthetic pathway or to the other newly established activities occurring within the nucleolus. The questions of how and why these proteins end up in this subnuclear compartment remain unanswered and are the focus of intense current interest. This review discusses our thoughts on the discovery of nonribosomal proteins in the nucleolus.
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© 2009 Pederson and Tsai This article is distributed under the terms of an Attribution– Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
DOI of Published Version
J Cell Biol. 2009 Mar 23;184(6):771-6. Epub 2009 Mar 16. Link to article on publisher's site
The Journal of cell biology
Pederson, Thoru and Tsai, Robert Y.L., "In search of nonribosomal nucleolar protein function and regulation" (2009). Open Access Articles. 2151.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.