Department of Biochemistry and Molecular Pharmacology
Chromatin; Computational Biology; Nucleosomes
Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics | Life Sciences | Medicine and Health Sciences
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed.
DOI of Published Version
J Biol. 2009 Dec 23;8(11):96. Link to article on publisher's site
Journal of biology
Hughes, Amanda and Rando, Oliver J., "Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC" (2009). Open Access Articles. 2146.