Department of Biochemistry and Molecular Pharmacology
Chromatin; Computational Biology; Nucleosomes
Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics | Life Sciences | Medicine and Health Sciences
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed.
DOI of Published Version
J Biol. 2009 Dec 23;8(11):96. Link to article on publisher's site
Journal of biology
Hughes A, Rando OJ. (2009). Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC. Open Access Articles. https://doi.org/10.1186/jbiol207. Retrieved from https://escholarship.umassmed.edu/oapubs/2146