Making synaptic plasticity and memory last: mechanisms of translational regulation

UMMS Affiliation

Program in Molecular Medicine

Publication Date


Document Type



Adaptor Proteins, Signal Transducing; Animals; Hippocampus; Memory; Phosphoproteins; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Synapses


Life Sciences | Medicine and Health Sciences


Synaptic transmission in neurons is a measure of communication at synapses, the points of contact between axons and dendrites. The magnitude of synaptic transmission is a reflection of the strength of these synaptic connections, which in turn can be altered by the frequency with which the synapses are stimulated, the arrival of stimuli from other neurons in the appropriate temporal window, and by neurotrophic factors and neuromodulators. The ability of synapses to undergo lasting biochemical and morphological changes in response to these types of stimuli and neuromodulators is known as synaptic plasticity, which likely forms the cellular basis for learning and memory, although the relationship between any one form synaptic plasticity and a particular type of memory is unclear. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, several types of memory formation and consolidation. Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation.

DOI of Published Version



Genes Dev. 2009 Jan 1;23(1):1-11. Link to article on publisher's site

Journal/Book/Conference Title

Genes and development

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Link to Article in PubMed

PubMed ID