Acute tryptophan depletion and sweet food consumption by overweight adults
Department of Medicine, Division of Preventive and Behavioral Medicine
Adult; *Body Mass Index; Dietary Carbohydrates; Dietary Proteins; Double-Blind Method; Female; *Food; *Food Preferences; Humans; Male; Overweight; Sweetening Agents; Tryptophan
Life Sciences | Medicine and Health Sciences
Serotonergic involvement has been implicated in preferential consumption of treat foods. We tested the effect of acute tryptophan depletion (ATD) on food consumption by overweight and lean adults with and without a history of recurrent major depressive disorder (MDD). ATD and taste-matched placebo challenges were administered double-blind in counter-balanced order. Participants were classified as lean (n=36) or overweight (n=19) on the basis of body mass index (BMI). Total calorie, carbohydrate, protein, and sweet food consumption were assessed via a test meal 8-h following ATD. Four food items of comparable palatability were offered as a part of the test: two sweet (one carbohydrate-rich, and one protein-rich) and two non-sweet (one carbohydrate-rich, and one protein-rich). As compared to the placebo challenge, ATD significantly increased sweet calorie intake among overweight participants and increased their propensity to consume sweet food first before any other type of food. Lean participants' sweet calorie intake and food preference were unaffected by ATD. Findings suggest serotonergic involvement in the sweet food consumption by overweight individuals.
DOI of Published Version
Eat Behav. 2009 Jan;10(1):36-41. Epub 2008 Oct 30. Link to article on publisher's site
Pagoto SL, Spring B, McChargue D, Hitsman B, Smith M, Appelhans B, Hedeker D. (2009). Acute tryptophan depletion and sweet food consumption by overweight adults. Open Access Publications by UMass Chan Authors. https://doi.org/10.1016/j.eatbeh.2008.10.010. Retrieved from https://escholarship.umassmed.edu/oapubs/2128