Glycemic status and brain injury in older individuals: the age gene/environment susceptibility-Reykjavik study
Authors
Saczynski, Jane S.Siggurdsson, Sigurdur
Jonsson, Palmi V.
Eiriksdottir, Gudny
Olafsdottir, Elin
Kjartansson, Olafur
Harris, Tamara B.
van Buchem, Mark A.
Gudnason, Vilmundur
Launer, Lenore J.
UMass Chan Affiliations
Department of Medicine, Division of Geriatric MedicineDocument Type
Journal ArticlePublication Date
2009-06-11Keywords
Age FactorsAged
Aged, 80 and over
Brain Injuries
Cerebral Infarction
Diabetes Mellitus, Type 2
Disease Susceptibility
Female
Humans
Male
Sex Factors
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
OBJECTIVE: To examine the association of glycemic status to magnetic resonance imaging indicators of brain pathological changes. RESEARCH DESIGN AND METHODS: This was a cross-sectional, population-based study of 4,415 men and women without dementia (mean age 76 years) participating in the Age Gene/Environment Susceptibility-Reykjavik Study. Glycemic status groups included the following: type 2 diabetes (self-report of diabetes, use of diabetes medications, or fasting blood glucose > or =7.0 mmol/l [11.1%]); impaired fasting glucose (IFG) (fasting blood glucose 5.6-6.9 mmol/l [36.2%]); and normoglycemic (52.7%). Outcomes were total brain volume, white and gray matter volume, white matter lesion (WML) volume, and presence of cerebral infarcts. RESULTS: After adjustment for demographic and cardiovascular risk factors, participants with type 2 diabetes had significantly lower total brain volume (72.2 vs. 71.5%; P < 0.001) and lower gray and white matter volumes (45.1 vs. 44.9%, P < 0.01 and 25.7 vs. 25.3%, P < 0.001, respectively) and were more likely to have single (odds ratio 1.45 [95% CI 1.14-1.85]) or multiple (2.27 [1.60-3.23]) cerebral infarcts compared with normoglycemic participants. Longer duration of type 2 diabetes was associated with lower total brain volume and gray and white matter volume, higher WML volume (all P(trend) < 0.05), and a greater likelihood of single and multiple cerebral infarcts (all P(trend) < 0.01). CONCLUSIONS: Type 2 diabetic participants have more pronounced brain atrophy and are more likely to have cerebral infarcts. Duration of type 2 diabetes is associated with brain changes, suggesting that type 2 diabetes has a cumulative effect on the brain.Source
Diabetes Care. 2009 Sep;32(9):1608-13. Epub 2009 Jun 9. Link to article on publisher's site
DOI
10.2337/dc08-2300Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39327PubMed ID
19509008Related Resources
Rights
© 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.Distribution License
http://creativecommons.org/licenses/by-nc-nd/3.0/ae974a485f413a2113503eed53cd6c53
10.2337/dc08-2300
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Except where otherwise noted, this item's license is described as © 2009 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.