UMMS Affiliation

Department of Cancer Biology

Publication Date

2009-09-01

Document Type

Article

Subjects

Apoptosis; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Microtubule-Associated Proteins; PTEN Phosphohydrolase; Tumor Suppressor Proteins

Disciplines

Cancer Biology | Life Sciences | Medicine and Health Sciences

Abstract

Despite the constant exposure to genomic insults that may lead to malignancy, cancer is surprisingly a relatively rare occurrence, and this is largely credited to an elaborate network of endogenous tumor suppression. Many effectors of tumor suppression have been identified, and their functions when activated in damaged cells have in large part been elucidated. What is less clear is whether there are common target gene(s) of tumor suppression, whose expression must be ablated in order to block transformation and preserve cellular homeostasis. Fresh experimental evidence suggests that silencing of the mitotic regulator and cell death inhibitor, survivin, is a universal requirement for successful tumor suppression in humans.

DOI of Published Version

10.4161/cc.8.17.9457

Source

Cell Cycle. 2009 Sep 1;8(17):2708-10. Epub 2009 Sep 7. Link to article on publisher's website

Journal/Book/Conference Title

Cell cycle (Georgetown, Tex.)

Comments

Co-author Minakshi Guha is a student in the Cancer Biology program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

19717980

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