Title

Regulation of Smad activities

UMMS Affiliation

Program in Molecular Medicine

Publication Date

2006-12-22

Document Type

Article

Subjects

Animals; Biological Transport; Cell Nucleus; Humans; Models, Biological; Phosphorylation; Smad Proteins; Smad Proteins, Receptor-Regulated; Smad4 Protein; Transforming Growth Factor beta

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

TGF-beta (Transforming Growth Factor-beta) cytokines employ Smad proteins as the intracellular mediator of signaling. Upon TGF-beta stimulation, the cytoplasmic Smads become phosphorylated and consequently accumulate in the nucleus to regulate target gene expression. The cytoplasm-to-nucleus redistribution of Smads, as well as the ability of Smads to activate or repress gene transcription, is under multiple layers of regulation by factors not limited to TGF-beta. With recent advance in the knowledge of regulatory factors impinged on Smads, we are beginning to understand the complexity in cellular responses to TGF-beta.

DOI of Published Version

10.1016/j.bbaexp.2006.11.001

Source

Biochim Biophys Acta. 2006 Nov-Dec;1759(11-12):503-13. Epub 2006 Nov 15. Link to article on publisher's site

Journal/Book/Conference Title

Biochimica et biophysica acta

Related Resources

Link to article in PubMed

PubMed ID

17182123

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