Title
Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans
UMMS Affiliation
Department of Anesthesiology
Publication Date
2008-2
Document Type
Article
Subjects
Adipose Tissue; Adult; Blood Pressure; Blood Volume; Electrocardiography; Female; Heart Rate; *Hemodynamics; Humans; Hydrogen-Ion Concentration; Hypovolemia; Lower Body Negative Pressure; Male; Models, Cardiovascular; Muscle, Skeletal; Oxygen; *Oxygen Consumption; Skin; *Spectrophotometry, Infrared; Stroke Volume; Time Factors; Vascular Resistance
Disciplines
Anesthesiology | Life Sciences | Medicine and Health Sciences | Physiology
Abstract
Ten healthy human volunteers were subjected to progressive lower body negative pressure (LBNP) to the onset of cardiovascular collapse to compare the response of noninvasively determined skin and fat corrected deep muscle oxygen saturation (SmO2) and pH to standard hemodynamic parameters for early detection of imminent hemodynamic instability. Muscle SmO2 and pH were determined with a novel near infrared spectroscopic (NIRS) technique. Heart rate (HR) was measured continuously via ECG, and arterial blood pressure (BP) and stroke volume (SV) were obtained noninvasively via Finometer and impedance cardiography on a beat-to-beat basis. SmO2 and SV were significantly decreased during the first LBNP level (-15 mmHg), whereas HR and BP were late indicators of impending cardiovascular collapse. SmO2 declined in parallel with SV and inversely with total peripheral resistance, suggesting, in this model, that SmO2 is an early indicator of a reduction in oxygen delivery through vasoconstriction. Muscle pH decreased later, suggesting an imbalance between delivery and demand. Spectroscopic determination of SmO2 is noninvasive and continuous, providing an early indication of impending cardiovascular collapse resulting from progressive reduction in central blood volume.
DOI of Published Version
10.1152/japplphysiol.00600.2007
Source
J Appl Physiol. 2008 Feb;104(2):475-81. Epub 2007 Nov 15. Link to article on publisher's site
Journal/Book/Conference Title
Journal of applied physiology (Bethesda, Md. : 1985)
Related Resources
PubMed ID
18006869
Repository Citation
Soller, Babs R.; Yang, Ye; Soyemi, Olusola O.; Ryan, Kathy L.; Rickards, Caroline A.; Walz, J. Matthias; Heard, Stephen O.; and Convertino, Victor A., "Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans" (2008). Open Access Articles. 2035.
https://escholarship.umassmed.edu/oapubs/2035