Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit
Department of Neurology
Brain Diseases; Calcium; Dantrolene; Humans; *Intensive Care; Muscle Relaxants, Central; Ryanodine Receptor Calcium Release Channel
Life Sciences | Medicine and Health Sciences
Calcium plays a central role in neuronal function and injury. Dantrolene, an inhibitor of the ryanodine receptor, inhibits intracellular calcium release from the sarco-endoplasmic reticulum. We review the available data of dantrolene as a potential neuroprotective agent and briefly summarize its other pharmacologic effects that may have potential applications for patients in the neurointensive care unit (NICU). Areas with the need for continued research are identified.
DOI of Published Version
Neurocrit Care. 2009;10(1):103-15. Epub 2008 Aug 12. Link to article on publisher's site
Muehlschlegel, Susanne and Sims, John R., "Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit" (2008). Open Access Articles. 1998.