Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit
UMass Chan Affiliations
Department of NeurologyDocument Type
Journal ArticlePublication Date
2008-08-13Keywords
Brain DiseasesCalcium
Dantrolene
Humans
*Intensive Care
Muscle Relaxants, Central
Ryanodine Receptor Calcium Release Channel
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Calcium plays a central role in neuronal function and injury. Dantrolene, an inhibitor of the ryanodine receptor, inhibits intracellular calcium release from the sarco-endoplasmic reticulum. We review the available data of dantrolene as a potential neuroprotective agent and briefly summarize its other pharmacologic effects that may have potential applications for patients in the neurointensive care unit (NICU). Areas with the need for continued research are identified.Source
Neurocrit Care. 2009;10(1):103-15. Epub 2008 Aug 12. Link to article on publisher's site
DOI
10.1007/s12028-008-9133-4Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39188PubMed ID
18696266Related Resources
ae974a485f413a2113503eed53cd6c53
10.1007/s12028-008-9133-4