Title

Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomas

UMMS Affiliation

Department of Pathology

Publication Date

2008-04-17

Document Type

Article

Subjects

Antigens, Neoplasm; Carcinoma, Papillary; Carcinoma, Renal Cell; Disease-Free Survival; Humans; Kidney Neoplasms; Neoplasm Proteins; RNA-Binding Proteins; Tumor Markers, Biological

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

BACKGROUND: Whether an oncofetal protein, IMP3, can serve as a prognostic biomarker to predict metastasis for patients with localized papillary and chromophobe subtypes of renal cell carcinomas (RCCs) was investigated.

METHODS: The expression of IMP3 in 334 patients with primary papillary and chromophobe RCC from multiple medical centers was evaluated by immunohistochemistry. The 317 patients with localized papillary and chromophobe RCCs were further evaluated for outcome analyses.

RESULTS: IMP3 was significantly increased in a subset of localized papillary and chromophobe RCCs that subsequently metastasized. Patients with localized IMP3-positive tumors (n=33; 10%) were over 10 times more likely to metastasize (risk ratio [RR], 11.38; 95% confidence interval [CI], 5.40-23.96; PCONCLUSIONS: IMP3 is an independent prognostic biomarker that can be used to identify a subgroup of patients with localized papillary and chromophobe RCC who are at high risk for developing distant metastasis.

DOI of Published Version

10.1002/cncr.23484

Source

Cancer. 2008 Jun 15;112(12):2676-82. Link to article on publisher's site

Journal/Book/Conference Title

Cancer

Related Resources

Link to Article in PubMed

PubMed ID

18412154

Share

COinS