UMMS Affiliation
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute
Publication Date
2008-11-14
Document Type
Article
Subjects
Animals; Brain Diseases; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Histone Deacetylases; Histones; Humans; Nervous System
Disciplines
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Abstract
It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.
DOI of Published Version
10.1523/JNEUROSCI.3797-08.2008
Source
J Neurosci. 2008 Nov 12;28(46):11753-9. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of neuroscience : the official journal of the Society for Neuroscience
Related Resources
PubMed ID
19005036
Repository Citation
Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC. (2008). Epigenetics in the nervous system. Open Access Articles. https://doi.org/10.1523/JNEUROSCI.3797-08.2008. Retrieved from https://escholarship.umassmed.edu/oapubs/1955
Comments
Co-author Yan Jiang is a student in the Neuroscience program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.