UMMS Affiliation
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute
Publication Date
2008-11-14
Document Type
Article
Subjects
Animals; Brain Diseases; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Histone Deacetylases; Histones; Humans; Nervous System
Disciplines
Life Sciences | Medicine and Health Sciences | Neuroscience and Neurobiology
Abstract
It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.
DOI of Published Version
10.1523/JNEUROSCI.3797-08.2008
Source
J Neurosci. 2008 Nov 12;28(46):11753-9. Link to article on publisher's site
Journal/Book/Conference Title
The Journal of neuroscience : the official journal of the Society for Neuroscience
Related Resources
PubMed ID
19005036
Repository Citation
Jiang, Yan; Langley, Brett; Lubin, Farah D.; Renthal, William; Wood, Marcelo A.; Yasui, Dag H.; Kumar, Arvind; Nestler, Eric J.; Akbarian, Schahram; and Beckel-Mitchener, Andrea C., "Epigenetics in the nervous system" (2008). Open Access Articles. 1955.
https://escholarship.umassmed.edu/oapubs/1955
Comments
Co-author Yan Jiang is a student in the Neuroscience program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.