Paramyxoviruses: different receptors - different mechanisms of fusion
Department of Molecular Genetics and Microbiology
Animals; Binding Sites; HN Protein; Hemagglutinins, Viral; Humans; Measles virus; *Membrane Fusion; Newcastle disease virus; Receptors, Virus; Viral Proteins
Life Sciences | Medicine and Health Sciences
Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.
DOI of Published Version
Trends Microbiol. 2008 Apr;16(4):135-7. Epub 2008 Mar 17. Link to article on publisher's site
Trends in microbiology
Iorio, Ronald M. and Mahon, Paul J., "Paramyxoviruses: different receptors - different mechanisms of fusion" (2008). Open Access Articles. 1951.