CD40 on APCs is needed for optimal programming, maintenance, and recall of CD8+ T cell memory even in the absence of CD4+ T cell help
UMass Chan Affiliations
Department of PathologyDocument Type
Journal ArticlePublication Date
2008-03-21Keywords
AnimalsAntigen-Presenting Cells
Antigens, CD40
Apoptosis
CD8-Positive T-Lymphocytes
Cell Differentiation
Dendritic Cells
Immunologic Memory
Mice
Mice, Knockout
Receptors, Interleukin-7
Signal Transduction
T-Lymphocytes, Helper-Inducer
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
CD40 stimulation is one of the many signals that can activate APCs and we have recently shown it to have a unique function in generating maximum primary CD8(+) T cell responses. However, whether CD40 signaling plays a role in memory CD8(+) T cell responses is still not completely understood. In this study, we show that in the absence of CD40 on all APCs or specifically on dendritic cells, memory CD8(+) T cells are generated but at significantly reduced levels. This reduction is due to a contribution of CD40 at several different steps in the generation of CD8(+) memory. In the initial T cell response, CD40 contributes to maximizing not only the number of effector cells that are generated but also the programming of ones that will differentiate into memory. Subsequently, CD40 is needed to maintain maximal numbers of the committed memory cells in a manner that is independent of the immunizing Ag. Finally, when memory CD8(+) T cells are reactivated there is a variable requirement for CD40 depending on whether CD40 or CD4(+) Th cells were present during the primary response. Therefore, CD40 signaling on APCs plays an important role in all phases of a memory CD8(+) T cell response.Source
J Immunol. 2008 Apr 1;180(7):4382-90.
DOI
10.4049/jimmunol.180.7.4382Permanent Link to this Item
http://hdl.handle.net/20.500.14038/39131PubMed ID
18354158Related Resources
ae974a485f413a2113503eed53cd6c53
10.4049/jimmunol.180.7.4382