Transcription factor functionality and transcription regulatory networks
UMass Chan Affiliations
Program in Gene Function and ExpressionDocument Type
Journal ArticlePublication Date
2008-03-21Keywords
DNAGenomics
Ligands
Protein Binding
Protein Processing, Post-Translational
Protein Structure, Tertiary
Transcription Factors
Transcription, Genetic
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Now that numerous high-quality complete genome sequences are available, many efforts are focusing on the "second genomic code", namely the code that determines how the precise temporal and spatial expression of each gene in the genome is achieved. In this regard, the elucidation of transcription regulatory networks that describe combined transcriptional circuits for an organism of interest has become valuable to our understanding of gene expression at a systems level. Such networks describe physical and regulatory interactions between transcription factors (TFs) and the target genes they regulate under different developmental, physiological, or pathological conditions. The mapping of high-quality transcription regulatory networks depends not only on the accuracy of the experimental or computational method chosen, but also relies on the quality of TF predictions. Moreover, the total repertoire of TFs is not only determined by the protein-coding capacity of the genome, but also by different protein properties, including dimerization, co-factor interactions and post-translational modifications. Here, we discuss the factors that influence TF functionality and, hence, the functionality of the networks in which they operate.Source
Mol Biosyst. 2008 Apr;4(4):309-14. Epub 2008 Feb 21. Link to article on publisher's siteDOI
10.1039/b715909aPermanent Link to this Item
http://hdl.handle.net/20.500.14038/39127PubMed ID
18354784Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1039/b715909a