Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine

Publication Date


Document Type



Adult; Aged; Biological Markers; *Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Dietary Carbohydrates; Female; *Glycemic Index; Humans; Linear Models; Longitudinal Studies; Male; Mental Recall; Middle Aged; Obesity; Prospective Studies


Community Health and Preventive Medicine | Dietetics and Clinical Nutrition | Life Sciences | Medicine and Health Sciences


OBJECTIVE: This study examined the relation between quality of dietary carbohydrate intake, as measured by glycemic index (GI) and glycemic load (GL), and serum high-sensitivity C-reactive protein (hs-CRP) levels.

METHODS: During a 1-y observational study, data were collected at baseline and at each quarter thereafter. GI and GL were calculated from multiple 24-h dietary recalls (24HRs), 3 randomly selected 24HRs at every quarter, with up to 15 24HRs per participant. The hs-CRP was measured in blood samples collected at baseline and each of the four quarterly measurement points. Multivariable linear mixed models were used to examine the cross-sectional and longitudinal associations of GI, GL, and hs-CRP.

RESULTS: Among 582 adult men and women with at least two measurements of diet and hs-CRP, average daily GI score (white bread = 100) was 85 and average GL was 198, and average hs-CRP was 1.84 mg/L. Overall, there was no association between GI or GL and hs-CRP. Subgroup analyses revealed an inverse association between GL and hs-CRP among obese individuals (body mass index > or =30 kg/m(2)).

CONCLUSION: Quality of dietary carbohydrates does not appear to be associated with serum hs-CRP levels. Among obese individuals, higher dietary GL appears to be related to lower hs-CRP levels. Due to the limited number of studies on this topic and their conflicting results, further investigation is warranted.

DOI of Published Version



Nutrition. 2008 May;24(5):401-6. Link to article on publisher's site

Journal/Book/Conference Title

Nutrition (Burbank, Los Angeles County, Calif.)

Related Resources

Link to Article in PubMed

PubMed ID