UMMS Affiliation

Department of Cancer Biology and Cancer Center

Publication Date

2008-06-06

Document Type

Article

Subjects

Animals; Antineoplastic Agents; Clinical Trials as Topic; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Integrins; Male; Neoplasm Metastasis; Neovascularization, Pathologic; Prostatic Neoplasms; Tumor Burden

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.

DOI of Published Version

10.1677/ERC-08-0019

Source

Endocr Relat Cancer. 2008 Sep;15(3):657-64. Epub 2008 Jun 4. Link to article on publisher's site

Journal/Book/Conference Title

Endocrine-related cancer

Related Resources

Link to Article in PubMed

PubMed ID

18524948

Share

COinS