Gene regulation in the third dimension
Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology
Animals; Cell Nucleus; Chromosomes; Chromosomes, Human; Epigenesis, Genetic; *Gene Expression Regulation; Humans; Models, Genetic; Regulatory Elements, Transcriptional; Regulatory Sequences, Ribonucleic Acid
Genetics and Genomics | Life Sciences | Medicine and Health Sciences
Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations.
DOI of Published Version
Science. 2008 Mar 28;319(5871):1793-4. Link to article on publisher's site
Science (New York, N.Y.)
Dekker, Job, "Gene regulation in the third dimension" (2008). Open Access Articles. 1924.