Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine

UMMS Affiliation

Center for Infectious Disease and Vaccine Research

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Adult; Antibodies, Viral; Antibody Specificity; Antigens, CD45; Antigens, CD8; Female; Humans; Immunologic Memory; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Interferon-gamma; Lymphocyte Count; Male; Neutralization Tests; T-Cell Antigen Receptor Specificity; T-Lymphocytes; *Vaccination


Life Sciences | Medicine and Health Sciences


Thirty adults were tested for humoral and cellular immune responses following immunization with the trivalent inactivated influenza vaccine. Modest but significant inverse correlations between the baseline and the fold changes in the number of IFNgamma-producing cells and the levels of neutralizing antibodies were observed. Specific increases in proliferative responses in the CD8 CD45RA+ population were noted after vaccination. Minimal correlations between neutralizing antibody titers and the number of IFNgamma-producing cells in terms of prevaccination levels or fold increases were observed. These results show specific increases in a CD8 T cell subset and discordant T and B responses induced by the trivalent inactivated influenza vaccine.

DOI of Published Version



Vaccine. 2008 Apr 7;26(16):1990-8. Epub 2008 Feb 26. Link to article on publisher's site

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