UMMS Affiliation

Department of Clinical Microbiology

Publication Date


Document Type



Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Haemophilus Infections; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Moraxella (Branhamella) catarrhalis; Respiratory Tract Infections; beta-Lactamases


Medical Microbiology


The in vitro activity of a new orally administered carbacephem analog of cefaclor, loracarbef (LY163892), was compared with those of cefaclor and several other oral antimicrobial agents against recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis. Loracarbef was found to be slightly more active than cefaclor against H. influenzae and had activity essentially equivalent to that of cefaclor for M. catarrhalis. Resistance to loracarbef was uncommon and was noted only with rare beta-lactamase-producing strains of H. influenzae. On the basis of these observations, loracarbef may be of utility in the management of localized, non-life-threatening infections caused by H. influenzae and M. catarrhalis.


Antimicrob Agents Chemother. 1991 Jul;35(7):1504-7.

Journal/Book/Conference Title

Antimicrobial agents and chemotherapy

Related Resources

Link to article in PubMed

PubMed ID




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