Department of Clinical Microbiology
Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Haemophilus Infections; Haemophilus influenzae; Humans; Microbial Sensitivity Tests; Moraxella (Branhamella) catarrhalis; Respiratory Tract Infections; beta-Lactamases
The in vitro activity of a new orally administered carbacephem analog of cefaclor, loracarbef (LY163892), was compared with those of cefaclor and several other oral antimicrobial agents against recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis. Loracarbef was found to be slightly more active than cefaclor against H. influenzae and had activity essentially equivalent to that of cefaclor for M. catarrhalis. Resistance to loracarbef was uncommon and was noted only with rare beta-lactamase-producing strains of H. influenzae. On the basis of these observations, loracarbef may be of utility in the management of localized, non-life-threatening infections caused by H. influenzae and M. catarrhalis.
Antimicrob Agents Chemother. 1991 Jul;35(7):1504-7.
Antimicrobial agents and chemotherapy
Doern, Gary V.; Vautour, Raymond; Parker, Douglas; Tubert, Tracy A.; and Torres, Brenda B., "In vitro activity of loracarbef (LY163892), a new oral carbacephem antimicrobial agent, against respiratory isolates of Haemophilus influenzae and Moraxella catarrhalis" (1991). Open Access Articles. 191.