Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

UMMS Affiliation

Program in Molecular Medicine; Howard Hughes Medical Institute

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Document Type



Amino Acid Sequence; Animals; CHO Cells; Cloning, Molecular; Cricetinae; *Gene Expression Regulation, Enzymologic; Humans; *JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase 7; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Protein Kinases; Sequence Alignment


Life Sciences | Medicine and Health Sciences


The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by phosphorylation on Thr and Tyr. Here we report the molecular cloning of a new member of the mammalian MAP kinase kinase group (MKK7) that functions as an activator of JNK. In vitro protein kinase assays demonstrate that MKK7 phosphorylates and activates JNK, but not the p38 or extracellular signal-regulated kinase groups of MAP kinase. Expression of MKK7 in cultured cells causes activation of the JNK signal transduction pathway. MKK7 is therefore established to be a novel component of the JNK signal transduction pathway.


Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42.

Journal/Book/Conference Title

Proceedings of the National Academy of Sciences of the United States of America

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