Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
Howard Hughes Medical Institute and Program in Molecular Medicine
*Adaptor Proteins, Signal Transducing; Animals; Gene Expression Regulation, Developmental; Gene Targeting; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Munc18 Proteins; Nerve Tissue Proteins; Proteins; Signal Transduction; Telencephalon; *Vesicular Transport Proteins; rhoA GTP-Binding Protein
Life Sciences | Medicine and Health Sciences
The murine JNK-interacting protein 3 (JIP3) protein (also known as JSAP1) is expressed exclusively in neurons and has been identified as a scaffold protein for the c-Jun NH2-terminal kinase (JNK) signaling pathway and as an adapter protein for cargo transport by the microtubule motor protein kinesin. To investigate the physiological function of JIP3, we examined the effect of Jip3 gene disruption in mice. The Jip3-/- mice were unable to breathe and died shortly after birth. Microscopic analysis demonstrated that Jip3 gene disruption causes severe defects in the morphogenesis of the telencephalon. Jip3-/- mice lack the telencephalic commissure, a major connection between the left and right hemispheres of the brain. The central nervous system abnormalities of Jip3-/- mice may be accounted for in part by a reduction in signal transduction by RhoA and its effector ROCK.
DOI of Published Version
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9843-8. Epub 2003 Aug 1. Link to article on publisher's site
Proceedings of the National Academy of Sciences of the United States of America
Kelkar, Nyaya; Delmotte, Marie Helene; Weston, Claire R.; Barrett, Tamera; Sheppard, Barbara J.; Flavell, Richard A.; and Davis, Roger J., "Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)" (2003). Open Access Articles. 1769.