13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
E. K. Shriver Center; Brudnick Neuropsychiatric Research Institute; Department of Psychiatry
Animals; Cell Division; Hippocampus; Immunohistochemistry; Isotretinoin; Maze Learning; Mice; Receptors, Retinoic Acid
Life Sciences | Medicine and Health Sciences
The active component of the acne drug Accutane is 13-cis-retinoic acid (RA), and it is highly teratogenic for the developing central nervous system. Very little is known, however, regarding the effect of this drug on the adult brain. Regions of the brain that may be susceptible to RA are those that continue to generate new neurons. In the adult mouse, neurogenesis is maintained in the hippocampus and subventricular zone. This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA.
DOI of Published Version
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5111-6. Epub 2004 Mar 29. Link to article on publisher's site
Proceedings of the National Academy of Sciences of the United States of America
Crandall, James E.; Sakai, Yasuo; Zhang, Jinhua; Koul, Omanand; Mineur, Yann; Crusio, Wim E.; and McCaffery, Peter J., "13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice" (2004). Open Access Articles. 1762.