UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

1988-06-10

Document Type

Article

Subjects

Animals; Aphidicolin; Cricetinae; Cricetulus; DNA Polymerase II; Deoxycytosine Nucleotides; Diterpenes; Female; Fibroblasts; Hela Cells; Ovary

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

17-Acetylaphidicolin was 10-fold weaker and two derivatives lacking hydroxyl groups at the 16 and 17 positions were 100-fold weaker than aphidicolin as inhibitors of DNA polymerase alpha from HeLa and Chinese hamster ovary cells. 17,18-Diacetyl, 3,17,18-triacetyl and 3-epi derivatives of aphidicolin were inactive. Active compounds were, like aphidicolin, competitive with dCTP and did not inhibit aphidicolin-resistant DNA polymerases.

Source

Nucleic Acids Res. 1988 Jun 10;16(11):5107-13.

Journal/Book/Conference Title

Nucleic acids research

Related Resources

Link to Article in PubMed

PubMed ID

3133639

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