UMMS Affiliation

Program in Molecular Medicine

Publication Date


Document Type



Activating Transcription Factors; Animals; Binding Sites; Blood Proteins; Cell Line; Cyclic AMP Response Element-Binding; Protein; DNA; Fungal Proteins; Gene Expression; Haplorhini; Macromolecular Substances; Plasmids; Protein Kinases; Recombinant Fusion Proteins; *Saccharomyces cerevisiae Proteins; Transcription Factors; Transcription, Genetic


Life Sciences | Medicine and Health Sciences


Cyclic AMP response element binding protein (CREB) activates transcription of cAMP response element (CRE)-containing promoters following an elevation of intracellular cAMP. Here we show that CREB and the highly related protein ATF-1 are also potent transcription inhibitors. Strikingly, CREB inhibits transcription of multiple activators, whose DNA-binding domains and activation regions are unrelated to one another. Inhibition requires that the CREB dimerization and DNA-binding domains are intact. However, inhibition is not dependent upon the presence of a CRE in the promoter, and does not involve heterodimer formation between CREB and the activator. The ability of an activator protein to inhibit transcription in such a promiscuous fashion has not been previously reported.


Nucleic Acids Res. 1993 Jun 25;21(12):2907-11.

Journal/Book/Conference Title

Nucleic acids research

Related Resources

Link to Article in PubMed

PubMed ID




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.