UMMS Affiliation

Program in Molecular Medicine

Publication Date


Document Type



Activating Transcription Factors; Animals; Binding Sites; Blood Proteins; Cell Line; Cyclic AMP Response Element-Binding; Protein; DNA; Fungal Proteins; Gene Expression; Haplorhini; Macromolecular Substances; Plasmids; Protein Kinases; Recombinant Fusion Proteins; *Saccharomyces cerevisiae Proteins; Transcription Factors; Transcription, Genetic


Life Sciences | Medicine and Health Sciences


Cyclic AMP response element binding protein (CREB) activates transcription of cAMP response element (CRE)-containing promoters following an elevation of intracellular cAMP. Here we show that CREB and the highly related protein ATF-1 are also potent transcription inhibitors. Strikingly, CREB inhibits transcription of multiple activators, whose DNA-binding domains and activation regions are unrelated to one another. Inhibition requires that the CREB dimerization and DNA-binding domains are intact. However, inhibition is not dependent upon the presence of a CRE in the promoter, and does not involve heterodimer formation between CREB and the activator. The ability of an activator protein to inhibit transcription in such a promiscuous fashion has not been previously reported.


Nucleic Acids Res. 1993 Jun 25;21(12):2907-11.

Journal/Book/Conference Title

Nucleic acids research

Related Resources

Link to Article in PubMed

PubMed ID