Chiaroscuro hematopoietic stem cell

UMMS Affiliation

Cancer Center

Publication Date


Document Type



Animals; Cell Differentiation; Cytokines; Female; Gene Therapy; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Male; Mice; Mice, Inbred BALB C; Models, Biological; Phenotype


Life Sciences | Medicine and Health Sciences


These observations suggest several immediate clinical strategies. In gene therapy, approaches could be targeted to obtain cycling of hematopoietic stem cells and gene-carrying retrovirus vector integration followed by engraftment at an appropriate time interval which favors engraftment. The same type of approach can be utilized for stem cell expansion approaches. Alternatively marrow or peripheral stem cell engraftment can be obtained with minimal to no toxicity in allochimeric strategies in such diseases as sickle cell anemia or thalassemia. A similar approach could be useful in obtaining cell engraftment with minimal toxicity in therapies employing cellular immune (T-cell and NK-cell) attack against cancer. These areas of clinical application are outline in Table 3.


Trans Am Clin Climatol Assoc. 1998;109:19-25; discussion 25-6.

Journal/Book/Conference Title

Transactions of the American Clinical and Climatological Association

Related Resources

Link to Article in PubMed

PubMed ID