A mammalian scaffold complex that selectively mediates MAP kinase activation

UMMS Affiliation

Program in Molecular Medicine; Howard Hughes Medical Institute

Publication Date


Document Type



Animals; COS Cells; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cell Line; Cercopithecus aethiops; Enzyme Activation; Interleukin-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; *MAP Kinase Kinase Kinases; *Mitogen-Activated Protein Kinase Kinases; *Mitogen-Activated Protein Kinases; Molecular Sequence Data; Protein Kinases; Protein-Serine-Threonine Kinases; Recombinant Fusion Proteins; *Signal Transduction


Life Sciences | Medicine and Health Sciences


The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.


Science. 1998 Sep 11;281(5383):1671-4.

Journal/Book/Conference Title

Science (New York, N.Y.)

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Link to Article in PubMed

PubMed ID