Antiphase oscillation of the left and right suprachiasmatic nuclei
Department of Neurology
Animals; Arginine Vasopressin; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Cycle Proteins; Circadian Rhythm; Cricetinae; *Gene Expression; Helix-Loop-Helix Motifs; In Situ Hybridization; Light; Male; Mesocricetus; Motor Activity; Nuclear Proteins; Suprachiasmatic Nucleus; Transcription Factors
Life Sciences | Medicine and Health Sciences
An unusual property of the circadian timekeeping systems of animals is rhythm "splitting," in which a single daily period of physical activity (usually measured as wheel running) dissociates into two stably coupled components about 12 hours apart; this behavior has been ascribed to a clock composed of two circadian oscillators cycling in antiphase. We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally "split" hamsters housed in constant light. The results show that the two oscillators underlying the split condition correspond to the left and right sides of the bilaterally paired SCN.
DOI of Published Version
Science. 2000 Oct 27;290(5492):799-801.
Science (New York, N.Y.)
de la Iglesia, Horacio O.; Meyer, Jennifer; Carpino, Alan; and Schwartz, William J., "Antiphase oscillation of the left and right suprachiasmatic nuclei" (2000). Open Access Articles. 1639.