Antiphase oscillation of the left and right suprachiasmatic nuclei

UMMS Affiliation

Department of Neurology

Publication Date


Document Type



Animals; Arginine Vasopressin; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cell Cycle Proteins; Circadian Rhythm; Cricetinae; *Gene Expression; Helix-Loop-Helix Motifs; In Situ Hybridization; Light; Male; Mesocricetus; Motor Activity; Nuclear Proteins; Suprachiasmatic Nucleus; Transcription Factors


Life Sciences | Medicine and Health Sciences


An unusual property of the circadian timekeeping systems of animals is rhythm "splitting," in which a single daily period of physical activity (usually measured as wheel running) dissociates into two stably coupled components about 12 hours apart; this behavior has been ascribed to a clock composed of two circadian oscillators cycling in antiphase. We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally "split" hamsters housed in constant light. The results show that the two oscillators underlying the split condition correspond to the left and right sides of the bilaterally paired SCN.


Science. 2000 Oct 27;290(5492):799-801.

Journal/Book/Conference Title

Science (New York, N.Y.)

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Link to Article in PubMed

PubMed ID