Department of Molecular Genetics and Microbiology
Amino Acid Sequence; Newcastle disease virus; Peptide Hydrolases; Protein Precursors; Structure-Activity Relationship; Viral Fusion Proteins
Life Sciences | Medicine and Health Sciences
Newcastle disease virus exhibits a wide range of pathogenicity and virulence which, as with all paramyxoviruses, is directly related to the cleavability of a precursor (F0) of the fusion glycoprotein by cellular proteases. Sequence analyses of the cleavage site of several virulent and avirulent isolates of the Newcastle disease virus serotype reveal a correlation between virulence or pathogenicity and a high content of basic amino acid residues at the cleavage site. A similar correlation has been seen for other paramyxoviruses.
J Virol. 1988 Jan;62(1):354-6.
Journal of virology
Glickman RL, Syddall RJ, Iorio RM, Sheehan JP, Bratt MA. (1988). Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus. Open Access Publications by UMMS Authors. Retrieved from https://escholarship.umassmed.edu/oapubs/1590