UMMS Affiliation

Department of Molecular Genetics and Microbiology

Publication Date

1988-01-01

Document Type

Article

Subjects

Amino Acid Sequence; Newcastle disease virus; Peptide Hydrolases; Protein Precursors; Structure-Activity Relationship; Viral Fusion Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Newcastle disease virus exhibits a wide range of pathogenicity and virulence which, as with all paramyxoviruses, is directly related to the cleavability of a precursor (F0) of the fusion glycoprotein by cellular proteases. Sequence analyses of the cleavage site of several virulent and avirulent isolates of the Newcastle disease virus serotype reveal a correlation between virulence or pathogenicity and a high content of basic amino acid residues at the cleavage site. A similar correlation has been seen for other paramyxoviruses.

Source

J Virol. 1988 Jan;62(1):354-6.

Journal/Book/Conference Title

Journal of virology

Related Resources

Link to Article in PubMed

PubMed ID

3275436

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