Program in Immunology and Virology; Department of Pathology
Acute Disease; Animals; Arenaviridae; Arenaviridae Infections; Chronic Disease; Interferons; Killer Cells, Natural; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Variation (Genetics)
Life Sciences | Medicine and Health Sciences
Pichinde virus (PV) strain AN 3739 was determined to be sensitive to natural killer (NK) cells in vivo by enhanced replication in NK-cell-depleted mice. An NK-sensitive subclone (PV-NKs1) was serially passed in mice whose NK cells had previously been activated by an interferon inducer, and two plaque isolates were shown to be resistant to NK cells but not to interferon. Inoculation of severe-combined-immunodeficient mice with PV-NKs1 led to a persistent infection resulting in an NK-resistant viral population. This is the first demonstration of the isolation of viral "NK-escape" variants, as defined by the ability of the virus to replicate in vivo.
J Virol. 1992 Apr;66(4):2532-5.
Journal of virology
Vargas-Cortes, Mauricio; O'Donnell, Carey L.; Maciaszek, Joseph Walter; and Welsh, Raymond M., "Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections" (1992). Open Access Articles. 1567.