UMMS Affiliation

Department of Molecular Genetics and Microbiology

Publication Date

1994-11-01

Document Type

Article

Subjects

Amino Acid Sequence; Molecular Sequence Data; Mutagenesis, Site-Directed; Newcastle disease virus; Structure-Activity Relationship; Viral Fusion Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Nonconservative mutations were introduced by site-specific mutagenesis into the fusion peptide and the adjacent heptad repeat region of the fusion protein of Newcastle disease virus in order to determine the role of both regions in the fusion activity of the protein. Mutations in both regions that allowed for proper folding and intracellular transport of the protein blocked the fusion activity of the protein when assayed in the presence of the hemagglutinin-neuraminidase protein.

Source

J Virol. 1994 Nov;68(11):7654-8.

Journal/Book/Conference Title

Journal of virology

Related Resources

Link to Article in PubMed

PubMed ID

7933158

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